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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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To address the bioaccumulation potential according to REACH requirements, the log Kow of N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide was measured applying slow stirring method according to OECD 123. The observed log Kow value (Log Kow>3) indicates that the substance may have a bioaccumulation potential if N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide would have been a narcotic substance. For polar narcotics like the N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide however there is only limited information on the relationship between log Kow and BCF. Performance of a standard aquatic exposure based OECD 305 test is however not considered.N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide sorbs easily to negatively charged surfaces like glassware, clay etc. and the parent is biodegraded into N-(2-aminoethyl)piperazine which has a shorter alkyl chain and a very low calculated log Kow. Maintaining steady state conditions in standard OECD 305 tests is complicated with these strongly sorbing easily degradable substances. In addition is the aquatic route of exposure unrealistic for these substances because the substance will either be sorbed or biodegraded.

N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide is thus quickly biodegraded into the metabolite N-aminoethylpiperazine (CAS no 140 -31 -8) and it is therefore very unlikely that N-[2-(piperazin-1 -yl) ethyl]C18 -insaturated-alkylamide will accumulate in the food chain. The metabolite formed; N-(2 -aminoethyl)piperazine is however considered persistent based on the currently available data but has a low bioaccumulation potential based on the low measured/calculated log Kow of -1.48/-1.57.

Bioaccumulation data on the structural analogue piperazine (CAS 110-85-0) support this conclusion: The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).

 

Reference: CERI(2004). Database of Biodegradation and Bio-Accumulation Data of Existingchemicals. Chemicals Evaluation and Research Institute, Japan. Available at http://www.nite.go.jp/en/chem/qsar/cscl_data.html