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EC number: 629-767-5 | CAS number: 1228186-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
To address the bioaccumulation potential according to REACH requirements, the log Kow of N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide was measured applying slow stirring method according to OECD 123. The observed log Kow value (Log Kow>3) indicates that the substance may have a bioaccumulation potential if N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide would have been a narcotic substance. For polar narcotics like the N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide however there is only limited information on the relationship between log Kow and BCF. Performance of a standard aquatic exposure based OECD 305 test is however not considered.N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide sorbs easily to negatively charged surfaces like glassware, clay etc. and the parent is biodegraded into N-(2-aminoethyl)piperazine which has a shorter alkyl chain and a very low calculated log Kow. Maintaining steady state conditions in standard OECD 305 tests is complicated with these strongly sorbing easily degradable substances. In addition is the aquatic route of exposure unrealistic for these substances because the substance will either be sorbed or biodegraded.
N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide is thus quickly biodegraded into the metabolite N-aminoethylpiperazine (CAS no 140 -31 -8) and it is therefore very unlikely that N-[2-(piperazin-1 -yl) ethyl]C18 -insaturated-alkylamide will accumulate in the food chain. The metabolite formed; N-(2 -aminoethyl)piperazine is however considered persistent based on the currently available data but has a low bioaccumulation potential based on the low measured/calculated log Kow of -1.48/-1.57.
Bioaccumulation data on the structural analogue piperazine (CAS 110-85-0) support this conclusion: The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).
Reference: CERI(2004). Database of Biodegradation and Bio-Accumulation Data of Existingchemicals. Chemicals Evaluation and Research Institute, Japan. Available at http://www.nite.go.jp/en/chem/qsar/cscl_data.html
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