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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.22 µg/L
Assessment factor:
50
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.022 µg/L
Assessment factor:
500
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
50 mg/L
Assessment factor:
1
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.831 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.083 mg/kg sediment dw
Extrapolation method:
sensitivity distribution

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
9.4 mg/kg soil dw
Assessment factor:
100
Extrapolation method:
assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral
PNEC value:
11.11 mg/kg food
Assessment factor:
1 800

Additional information

PNECs for N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide were based on (i) new generated data and (ii) existing data. When no data is available the equilibrium partitioning method is used for determining the relevant PNEC. One long-term terrestrial test is available with a NOEC of 940 mg a.i. /kg dw. The chemical safety assessment indicates no need to investigate further.

Conclusion on classification

Dangerous substance directive:

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide is considered as very toxic for the aquatic compartment.

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide is considered as not-persistent in the environment, based on the results of a ready biodegradation test and additional research. This additional work showed that N

-[2-(piperazin-1-yl)ethyl]C18 -insaturated-alkylamide is quickly degraded to form 1 -aminoethylpiperazine which has a low calculated log Kow.

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide has a high log Kow value but due to the rapid degradation of the bioavailable fraction there will be no-accumulation of N-[2 -(piperazin-1 -yl)ethyl]18 -insaturated-alkylaminde in the food chain. It is anticipated that this rapid degradation will also occur in fish.

Therefore based on the above mentioned results N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide is classified as follows:

N-R50/53

Classification Labeling & Packaging:

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide is considered as very toxic for the aquatic compartment.

N-[2 -(piperazin-1 -yl)ethyl]C18 -insaturated-alkylamide is considered as non-persistent in the environment, based on the results of a ready biodegradation test and additional research.

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide has a high log Kow value but due to the rapid degradation of the bioavailable fraction there will be no accumulation of

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide in the food chain. It is anticipated that the observed rapid degradation of the bioavailable fraction will also occur in fish.

The chronic data available for

N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide are as follows: NOEC_algae (72h) = 0.011 mg/L and NOEC_daphnia (21d) = 0.37 mg/L

Therefore based on the above mentioned results and according to the new version of CLP (03.2011), N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide is classified as follows:

Aquatic acute category 1 - H400

Aquatic chronic category 2 – H411

The lowest L(E)C50 value obtained in the frame of the ecotoxicity tests being 0.037 mg/L (algae), the M factor is:

M-factor acute = 10

M factor chronic = 1