Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-792-6 | CAS number: 375-72-4
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolytic half life at ca. 23 °C (19F NMR method similar to OECD TG111):
pH 4: > 7 days
pH 7: 72.9 ± 2.0 hours
pH 9: 24.1 ± 0.6 hours
Key value for chemical safety assessment
Additional information
The key study was equivalent to OECD TG111 and was conducted taking PBSF's volatility into account. The system was buffered sufficiently to neutralize all all acid products assuming 100% hydrolysis (ca. 500 mM buffer). Detection was by 19F NMR and the method had a limit of detection sufficient to determine 0.09% hydrolysis of starting material. Extent of hydrolysis was followed by monitoring the expected hydrolysis product perfluorobutanesulfonic acid. The study was conducted under ISO9001/2008 guidelines and was done using sound scientific principles similar to OECD TG111. The study is reliable with restrictions and is suitable for assessing hydrolysis of PBSF. The supporting study was done according to EPA OPPTS 835.2110 and was GLP compliant. However, in several cases tested at lower concentrations, PBSF was lost from the test bottles without appearance of hydrolysis products. At higher concentrations, PBSF was not lost but significant hydrolysis was not observed. The test vials in the supporting study do not appear to have been shaken during the experiment and were only mixed on initial setup. Buffer concentrations in the supporting study were less than 10% (6-25 mM) of those in the key study. It is believed that the test substance was lost by volatilization during the experimental and/or analytical phases of the supporting study. The supporting study suggests that volatilization may be more important than hydrolysis under some circumstances. Further, the lack of hydrolysis in less buffered, unmixed vials as compared to extensive hydrolysis in highly buffered, well-mixed vials suggests that ionic strength and/or extent of mixing has a strong impact on hydrolysis rate. Since PBSF is insoluble (< 0.274 mg/L) in water, it is likely that the latter is the case.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
