Registration Dossier
Registration Dossier
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EC number: 939-728-7 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a reverse gene mutation assays in bacteria, performed according to the OECD guideline 471 and in compliance with GLP, Menthanyl acetate multiconstituent was negative in S. typhimurium strains ( TA 1535, TA 1537, TA 98, TA 100 and TA 102) in presence and absence of metabolic activation, up to limit or cytotoxic concentrations.
Menthanyl acetate multiconstituent was also negative in presence and absence of metabolic activation in a chromosome aberration test performed in cultured human lymphocytes performed according to OECD guideline 473 and in compliance with GLP.
Menthanyl acetate multiconstituent was also negative in presence and absence of metabolic activation in a gene mutation test (HPRT) in L5178Y tk+/-(3.7.2C) mouse lymphoma cells performed according to OECD guideline 476 and in compliance with GLP.
Justification for selection of genetic toxicity endpoint
No robust study summary was chosen for this endpoint because more than one study was used to complete this endpoint; therefore, it was not possible to select only one of the studies used for this endpoint.
Short description of key information:
Menthanyl acetate multiconstituent was found negative in all in vitro mutagenicity tests available (Ames test and HPRT test). It was also negative in chromosome aberration test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
As Menthanyl acetate multiconstituent is negative in all in vitro tests performed (mutagenicity in bacteria, mutagenicity in mammalian cells and clastogenicity tests), it is not classified according to the annex VI of the Directive 67/548/EEC and the CLP Regulation (EC) No. 1272 -2008.
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