Registration Dossier
Registration Dossier
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EC number: 206-851-6 | CAS number: 383-63-1
Endpoint summary
Administrative data
Description of key information
Additional information
Stability:
To assess the stability of Ethyl trifluoroacetate (TFAE), one valid study report, five publications and one recent study were available.
The key study is an algae growth range-finding test in combination with an analytical hydrolysis test. Based on the results of the preliminary and range-finding studies, it can be concluded that TFAE is rapidly converted to TFA, in 57 minutes (half-life of TFAE is < 1 hour).
Furthermore, the results of the five publications and the recent study support the fact that TFAE is rapidly hydrolysed.
Based on these data, TFAE reacts with water and is degraded in TFA and ethanol. A read across strategy is used with TFA which is the relevant substance for risk assessment and classification and labelling purposes. However, in aqueous solution, the pH of this substance is naturally low and for testing under realistic environmentally conditions either the sodium salt (NaTFA) or pH adjustment are required.
Biodegradation:
To assess the biodegradation of TFAE in water, two key studies are available on NaTFA.
The first study is a ready biodegradability test, performed by Van Ginkel in 1992, according to slightly modified OECD 301D, EEC 1984 Part C., and ISO Test Guidelines. The percentages biodegradation of NaTFA were 0% for 0, 7, 21, 28 and 77 days and 8% for 14 and 42 days. However, the results of the prolonged test are invalid because the differences of extremes of replicate values of the removal of the test chemical at 77 days are 95% (> 20%). Moreover, the result of 8% degradation at day 42 is probably an artifact due to the 40 % coefficient of variation between duplicate values of the control. In conclusion, NaTFA is not biodegraded in the closed bottle test (28 days) and should therefore not be classified as readily biodegradable.
The second study is an inherent biodegradability test, performed also by Van Ginkel in 1992, according to OECD Guideline 302 A and EEC Directive 87/302. NaTFA caused no reduction of the biodegradation of the NPOC present in primary settled waste water. Therefore, NaTFA is considered to be non-inhibitory to the activated sludge. Biodegradation of TFA has to lead to the formation of fluoride. Fluoride was not detected in the effluent of both SCAS units. This result also demonstrates that NaTFA is not biodegraded in the SCAS test.
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