Registration Dossier
Registration Dossier
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EC number: 240-759-7 | CAS number: 16712-64-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Adequacy of study:
- weight of evidence
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report for 3-Hydroxy-2-naphthoic acid CAS: 92-70-6
- Author:
- Organisation for Economic Co-Operation and Development (OECD)
- Year:
- 2 004
- Bibliographic source:
- http://www.chem.unep.ch/irptc/sids/OECDSIDS/92706.pdf
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
- Reference substance name:
- 97-70-6
- IUPAC Name:
- 97-70-6
- Reference substance name:
- 3-HNA
- IUPAC Name:
- 3-HNA
- Test material form:
- other: 12% solution of the test substance in a mixture of acetone and olive oil
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- guinea pig
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: mixture of acetone and olive oil
- Duration of exposure:
- 24 hours
- Doses:
- 12% solution of test substance
- No. of animals per group:
- No data.
- Details on study design:
- none available
Results and discussion
- Signs and symptoms of toxicity:
- yes
Applicant's summary and conclusion
- Conclusions:
- Evidence for dermal absorption based on both local and systemic effects upon dermal application.
- Executive summary:
Based on systemic toxicity (single animal mortality), as well as local effects (edema, necrosis, and subcutaneous hemorrhage), dermal absorption is assumed to occur.
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