2,2-bis(hydroxymethyl)butanoic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Version / remarks:

92/69/EEC, C1 (Limit test)

GLP compliance:

yes

Analytical monitoring:

yes

Remarks:

measured concentrations over the first and last 24 hours of the exposure period were 101 - 89.4 mg/l and 105 - 104 mg/l respectively

Details on test solutions:

Identity and concentration of auxiliary solvent for dispersal: None.

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Test type:

static

Limit test:

yes

Total exposure duration:

96 h

Hardness:

CA 170 mg CaCO3/L

Nominal and measured concentrations:

nominal: 100 mg/L

measured concentrations over the first and last 24 hours of the exposure period were 101 - 89.4 mg/l and 105 - 104 mg/l respectively

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

ca. 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

72 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Details on results:

%Concentration loss over test: 0

Conclusions:

No mortalities or sublethal effects were seen

Executive summary:

Study was performed according to OECD 203 guidance under GLP condition as a limit test. The total duration of the test was 96 hours. The test with Oncorhynchus mykiss (previous name: Salmo gairdneri) was performed under static condition. The measured test concertation over the first and last 24 hours of the exposure period were 101 - 89.4 mg/l and 105 - 104 mg/l respectively. During whole testing period no mortalities or sublethal effects were seen. The LC 50 based on fish mortality was established as more than 100mg/L. The NOEC (no observed effect concertation) was established as 100 mg/L (based on fish mortality).

Description of key information

Study was performed according to OECD 203 guidance under GLP condition as a limit test. The total duration of the test was 96 hours. The test with Oncorhynchus mykiss (previous name: Salmo gairdneri) was performed under static condition. The measured test concertation over the first and last 24 hours of the exposure period were 101 - 89.4 mg/l and 105 - 104 mg/l respectively. During whole testing period no mortalities or sublethal effects were seen. The LC 50 based on fish mortality was established as more than 100mg/L. The NOEC (no observed effect concertation) was established as 100 mg/L (based on fish mortality).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

EC50

Effect concentration:

> 100 mg/L