Registration Dossier
Registration Dossier
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EC number: 229-662-0 | CAS number: 6642-31-5
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- until 2002-08-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- estimation of the dissociation constants (pKa-values)
- GLP compliance:
- not specified
- Dissociating properties:
- ambiguous
- No.:
- #1
- pKa:
- 7
- Remarks on result:
- other: Primary Amine, Taft
- Remarks:
- Test item can be protonated at the primary amino group in aqueous solutions.
- Conclusions:
- 1,3-Dimethyl-4-aminouracil can be protonated at the primary amino group in aqueous solutions (pKa = 7)
- Executive summary:
1,3-Dimethyl-4-aminouracil can be protonated at the primary amino group in aqueous solutions (pKa = 7)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- scientifically acceptable, well documented guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- no
Referenceopen allclose all
The test item in aqueous solution could neither be protonated with 0.1 mol/l hydrochloric acid nor deprotonated with 0.1 mol/l
sodium hydroxide solution.
The determination of the dissociation constant of the test item was not possible.
Description of key information
Dissociation constant
- 1,3-Dimethyl-4-aminouracil can be protonated at the primary amino group in aqueous solutions (pKa = 7) (calculation)
- The determination of the dissociation constant of the test item was not possible. The substance does not contain any ionic structure. (OECD 112, GLP)
Key value for chemical safety assessment
- pKa at 20°C:
- 7
Additional information
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