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Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002-06-12 (experimental phase)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
adopted July 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
EEC Directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.1 "Melting/Freezing temperature", EEC Publication No. L383, December 1992.
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
thermal analysis
Remarks:
via Differential Scanning Calorimeter
Specific details on test material used for the study:
- Storage condition of test material: at room temperature (at about 20 °C)
Key result
Melting / freezing pt.:
299 °C
Atm. press.:
1 013 hPa
Decomposition:
no
Remarks on result:
other:
Remarks:
Mean of two runs. During these runs, the samples lost 24.3 % and 37.3 % of their mass, respectively. After the measurement both samples were colored brownish yellow and of a clear melt.

The melting point of 1,3-DIMETHYL-4-AMINOURACIL was determined to be 299.0 °C±0.5°C which is equal to 572.2 K ± 0.5 K.

Conclusions:
The melting point of 1,3-DIMETHYL-4-AMINOURACIL is 299.0 °C±0.5°C.
Executive summary:

The determination of the melting point / melting range of the test item was performed according to the EEC Directive 92/69, A.1 "Melting/Freezing temperature", December 1992 and to the OECD Guideline No. 102;" Melting point / melting range", adopted July 27, 1995, under GLP. Thermal analysis was performed using a DSC apparatus.

The DSC-curve of the preliminary test (heating rate of 20 K/min from 25 °C to 400 °C) shows that an endothermic heat effect, the melting, was observed at 304.7 °C. After the experiment, the sample had lost about 62 % of its mass and the color of the sample was brownish black and carbonized.

In order to determine the melting more precisely, further DSC-runs were recorded between 275 °C and 325 °C with a heating rate of 5 K/min. In the first main test run, the melting of 1,3-DIMETHYL-4-AMINOURACIL was determined at 299.4 °C. The melting of the test item during the second main test run was determined to be at 298.7 °C. During these runs, the samples lost 24.3 % and 37.3 % of their mass, respectively.

In conclusion, the melting point of 1,3-DIMETHYL-4-AMINOURACIL was determined to be 299.0 °C±0.5°C.

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
yes (incl. QA statement)
Type of method:
thermal analysis
Key result
Melting / freezing pt.:
296 °C
Atm. press.:
1 013 hPa
Decomposition:
no
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer reviewed database
Guideline:
other: no data
GLP compliance:
no
Key result
Melting / freezing pt.:
295 °C

Description of key information

Melting Point:

296°C at 1013 hPa (thermal analysis, OECD 102, GLP)

295°C (database entry)

299°C at 1013 hPa (thermal analysis, OECD 102, GLP)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
299 °C

Additional information