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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
until 2002-07-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: The melting point of 1,3-DIMETHYL-4-AMINOURACIL was determined. Using the estimated boiling point of 1.3-DIMETHYL-4-AMINOURACIL, the vapour pressure was calculated using the Modified Watson Correlation.
Specific details on test material used for the study:
Colour: White
Aggregate State at Room Temperature: Solid
Molecular Weight: 155.16 g/mol
Molecular Formula: C6H9N3O2
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa

The boiling point of 1.3-DIMETHYL-4-AMINOURACIL was estimated to be above 400 °C. The melting point of 1.3-DIMETHYL-4-AMINOURACIL was determined to be 299 °C. A temperature range up to 400 °C was tested. In this temperature range no boiling of 1.3-DIMETHYL-4-AMINOURACIL was observed. Therefore it was supposed, that the boiling point of 1,3-DIMETHYL-4-AMINOURACIL is above 400 °C. For the calculation of the vapour pressure a estimated boiling point of 400 °C was used.

Conclusions:
The GLP study was performed according to the EEC directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.4 "Vapour Pressure", EEC Publication No. L383, December 1992 and the OECD Guideline No. 104, "Vapour Pressure", adopted July 27, 1995.
The vapour pressure of the test substance was estimated to be 1.0 x 10E-7 Pa. This procedure is considered scientifically reasonable as is supported by the requirements under REACH: "The study does not need to be conducted if the melting point is above 300 °C. If the melting point is between 200 °C and 300 °C, a limit value based on measurement or a recognised calculation method is sufficient."
Executive summary:

The GLP study was performed according to the EEC directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.4 "Vapour Pressure", EEC Publication No. L383, December 1992 and the OECD Guideline No. 104, "Vapour Pressure", adopted July 27, 1995.

The boiling point of 1.3-DIMETHYL-4-AMINOURACIL was estimated to be above 400 °C. The melting point of the substance was determined to be 299 °C. A temperature range up to 400 °C was tested. In this temperature range no boiling of 1.3-DIMETHYL-4-AMINOURACIL was observed. Therefore it was supposed, that the boiling point of 1,3-DIMETHYL-4-AMINOURACIL is above 400 °C. For the calculation of the vapour pressure a estimated boiling point of 400 °C was used.The vapour pressure of the test substance was estimated to be 1.0 x 10E-7 Pa at 25 °C based on the estimated boiling point of 400°C and using the Modified Watson Correlation.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Temp.:
20 °C
Vapour pressure:
< 0 hPa
Temp.:
50 °C
Vapour pressure:
< 0 hPa

Description of key information

Vapour pressure:

< 1 * 10exp(-6) hPa at 20°C resp. 50°C (effusion method: by loss of weight or by trapping vaporisate, OECD 104, GLP)

7.53 * 10exp(-6) mm Hg at 25°C (database entry, QSAR estimation)

1 * 10exp(-7) hPa at 25°C (calculated using the Modified Watson Correlation, OECD 104, GLP)

Key value for chemical safety assessment

Vapour pressure:
0 hPa
at the temperature of:
25 °C

Additional information