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EC number: 214-002-6 | CAS number: 1072-15-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
skin irritation (OECD 404): irritating
eye irritation (OECD 405): highly irritating/corrosive
SCLs according to GHS:
>=10% - <20% Eye Irrit. Cat.2
<10% No Classification
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
According to the HERA report AS with longer carbon chains (C16-18) tend to be less irritating than AS with carbon chains of C12-15. Moreover, regarding the counter cation, the irritating potential decreases in the order potassium, sodium, ammonium.
The experimental data for skin and eye irritation show that AS have to be classified regardless the chain length as R38-41 (Skin Irri.2 - Eye Dam.1)
To set a specific concentration limit for the R36-41 (Eye Irri.2 - Eye Dam.1) cut off, the study conducted with C12-13, K (Cas # 91783-22-1) can be taken as reference. This substance represents a worst-case in the chain length as well as the counter cation and triggers at 22% a.s. a R36 (Eye Irrit.2) classification with borderline to R41 (Eye Dam.1). This justifies a SCL of 20% for all AS.
The first study conducted with C10-16, Na (Cas # 68585-47-7) shows,depending on the classification requirements, that the test substance is not or only moderate irritating to the eye at a concentration of 10% a.s. The second study with C10-16, Na (CAS#68585-47-7, analytical purity 10%) shows that the test substance is not irritating. Based on the above mentioned results with different concentrations of structurally related alkyl sulfates a cut of value for classification as severe irritating to eyes at 20% and for classification as irritating at 10% for all AS is justifiable.
The following information is taken into account for any hazard / risk assessment:
Existing data indicate that for classification for skin and eye irritation is justified (R38-41).
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: highly irritating
Specific concentration limits for eye irritation can be set as follows:
>= 20%: R41
>=10% - <20%: R36
Justification for selection of skin irritation / corrosion endpoint:
Reliable OECD guideline study
Justification for selection of eye irritation endpoint:
Reliable OECD guideline study
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
According to the classification criteria of Directive 67/548/EEC and Regulation (EC) No 1272/2008 the test substance needs to be classified with Xi, R38/R41 and Skin Irritation Category 2, H315 and Eye Dam.1, H318, respectively.
It could be shown with experimental data on eye irritation that at 10 to 20% active substance only the classification Eye Irritating Category 2 according to Regulation (EC) No 1272/2008 and according to Directive 67/548/EEC only the classification R36 remains. Below 10% active substance no classification at all is necessary. Hence, the Generic Concentration Limits (GCLs) can be substituted by the mentioned specific ones (SCLs).
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