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Two studies show that p-TSA is readily biodegradable; one is a publication, valid with restrictions, in which the degradation pathway is described and from which can be concluded that p-TSA is readily biodegradable and the other is a full GLP Closed bottle Test according to standard guideline which shows that p-TSA is readily biodegradable and not toxic to the microorganisms at 2 mg/L.

p-TSA is also completely mineralized in soil as can be seen from a study with Chloramine-T (CAS 127 -65 -1) Chloramine-T trihydrate is a strong oxidizing agent in aqueous solution and when brought into contact with organic matter (soil) it reacts and leaves p-tolunenesulfonamide as the only detectable transformation product. The rate and route of p-toluenesulfonamide biodegradation depends on the soil type. But in each tested soil type p-toluenesulfonamide is totally mineralised.

Sandy loam soil: Disappearance of p-toluenesulfonamide was calculated with DT50 and DT90 values of 30 days and 110 days, respectively.

Humic sand soil: Disappearance of p-tofuenesulfonamide was calculated with DT50 and DT90 values of 68 days and 249 days, respectively. 

Low humic content sand soil: The DT50 and DT90 values for the disappearance of p-toluenesulfonamide were estimated to be between 28 days and 56 days.