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Only acute data on aquatic toxicity to algae is available for amantadine hydrochloride. An analogy approach to amantadine, which has a similar structure, was used regarding acute toxicity to fish and aquatic invertebrates. The EC50 values are 25 mg/L and 24.4 mg/L for fish and daphnia, respectively. For algae, the EC50 was estimated to be 62.1 mg/L