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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
24.4 mg/L

Additional information

There is no data available on the toxicity of amantadine hydrochloride on aquatic invertebrates. The assessment of toxicity to aquatic invertebrates is based on data obtained for the similar substance amantadine, in a static test performed according to the EPA OTS 797.1300 guideline, using the the water flea (Daphnia magna) as test organism. An EC50 value of 24.4 mg/L was derived for 48 hours exposure (Pedersen et al., 2000).