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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very old study, Non GLP, single dose, no details available

Data source

Reference
Reference Type:
publication
Title:
Studien über die Wirkung der Chloraniline und Chlortoluidine und des salzsauren 5-Chlor-2-toluidins
Author:
Lehmann et. al.
Year:
1933
Bibliographic source:
Arch. Hyg. Bakteriol. 110, 12-32

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
5-chloro-o-toluidine
EC Number:
202-452-6
EC Name:
5-chloro-o-toluidine
Cas Number:
95-79-4
Molecular formula:
C7H8ClN
IUPAC Name:
5-chloro-2-methylaniline

Test animals

Species:
cat
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Fat vehicle not further specified

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
other: 100 % mortallity after 4 days
Effect level:
1 667 mg/kg bw
Based on:
not specified
Sex:
male
Dose descriptor:
other: 100 % mortallity after 3 days
Effect level:
1 111 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Because it is known that 5-chloro-o-toluidine can be resorped through the skin and that it causes cyanosis, the substance should be classified as harmful in contact with skin.