Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.12 (Mikrokerntest)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3,4,5-tetrachlorobenzoylchloride
EC Number:
406-760-3
EC Name:
2,3,4,5-tetrachlorobenzoylchloride
Cas Number:
42221-52-3
Molecular formula:
C7HCl5O
IUPAC Name:
2,3,4,5-tetrachlorobenzoyl chloride
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
other: mus, NMRI

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
Maisöl
No. of animals per sex per dose:
Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 72 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 72 hours

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
yes
Remarks:
(Doses producing toxicity: 1000 mg/kg)
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid
Additional information on results:
Observations:
Klinische Symptome; letale Effekte; cytotoxische Effekte
"ENGLISH"
Clinical symptoms: lethal effects, cytotoxic effects

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative