Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
other information
Study period:
3-5 August 2009
Reliability:
1 (reliable without restriction)

Data source

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: OECD 202 "Daphnia sp., Acute immobilisation Test"
Qualifier:
according to guideline
Guideline:
other: Commission Regulation (EC) No 440/2008 of 30 May 2008, Part C: Methods for the determination of ecotoxicity, Publication No. L142, C.2. "Daphnia Sp. Acute Immobilisation Test".
Qualifier:
according to guideline
Guideline:
other: ISO International Standard 6341: "Water quality - Determination of the inhibition of the mobility of Daphnia magna Straus - Acute toxicity test, Third edition, 1996-04-01.
Qualifier:
according to guideline
Guideline:
other: Guidance document on aquatic toxicity testing of difficult substances and mixtures, OECD series on testing and assessment number 23, December 14, 2000.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
EC Number:
618-883-1
Cas Number:
92878-95-0
Molecular formula:
C10H12ClNO4
IUPAC Name:
2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
Details on test material:
The batch of WAY-188471 tested was a slightly yellow powder with a purity of 99.8% and not
completely soluble in test medium at the concentrations tested.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
not specified
Total exposure duration:
48 h

Results and discussion

Effect concentrationsopen allclose all
Dose descriptor:
NOEC
Effect conc.:
ca. 8.5 mg/L
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
>= 8.5 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
>= 8.5 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present study WAY-188471 did not induce acute immobilisation of Daphnia magna at 8.51 mg/l after 48 hours of exposure (NOEC).
The 48h-EC50 was beyond the range tested, i.e. exceeded an initial concentration of 8.5 mg/l.
Due to the very low solubility of WAY-188471 in water, concentration levels that might be toxic for Daphnia magna could not be reached.