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EC number: 807-654-3 | CAS number: 1627851-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20-23 Mar 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Groupe interministeriel des produits chimiques, Ivry sur Seine, France
Test material
- Reference substance name:
- (2R,3R,4S,5S,6R)-2-(heptyloxy)-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-6-(heptyloxy)-3,4,5-trihydroxyoxan-2-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-6-{[(2R,3S,4S,5R,6R)-6-(heptyloxy)-3,4,5-trihydroxyoxan-2-yl]methoxy}-3,4,5-trihydroxyoxan-2-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol
- EC Number:
- 807-654-3
- Cas Number:
- 1627851-18-6
- Molecular formula:
- (C6H10O5)nC7H16O, n - number of D-glucopyranose units
- IUPAC Name:
- (2R,3R,4S,5S,6R)-2-(heptyloxy)-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-6-(heptyloxy)-3,4,5-trihydroxyoxan-2-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-6-{[(2R,3S,4S,5R,6R)-6-(heptyloxy)-3,4,5-trihydroxyoxan-2-yl]methoxy}-3,4,5-trihydroxyoxan-2-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol
- Test material form:
- other: solid, not further specified
- Details on test material:
- - Name of test material (as cited in study report): Heptylglucoside
- Physical state: solid
- Analytical purity: < 99% dry matter
- Lot/batch No.: 3675 JG
- Expiration date of the lot/batch: 16/01/2016
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: SkinEthic model, in vitro human reconstructed epidermis
- Details on test animals or test system and environmental conditions:
- TEST SKIN MODEL
- Source: SkinEthic, Lyon, France
TEST METHOD
Skin Ethic RHE/S/17:
0.5 cm² reconstructed epidermis of normal human keratinocytes. Cells are grown on inert polycarbonate filter on chemically defined medium, airlifted for 17 days. Irritant materials are identified by their ability to penetrate the stratum corneum and to damage the underlaying cell layers which is determined through a decrease in cell viability as determined by MTT reduction assay.
ADAPTATION TO CELL CULTURE CONDITIONS
Upon receipt, tissues were transferred into 6-well plates containing 2 mL of growth medium in a humidified incubator for at least 1 h (37 ± 1 °C, 5% CO2) before use.
INCUBATION CONDITIONS (INCUBATOR)
- Temperature (°C): 37
- CO2 gas concentration (%): 5
- Humidity: saturated
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: Intact reconstructed epidermis
- Vehicle:
- other: PBS
- Controls:
- other: concurrent control tissues treated with PBS served as negative controls, positive controls were exposed to 5% SDS.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 16 ± 2 mg
POSITIVE CONTROL SUBSTANCE:
- Positive control substance: SDS, 5 % (v/v), 16 ± 0.5 µL - Duration of treatment / exposure:
- 42 ± 1 min
- Observation period:
- Not applicable. Post-treatment incubation period: 42 ± 1 h.
- Number of animals:
- Not applicable. The test was performed in triplicates for each treatment and control group.
- Details on study design:
- TEST SITE
- Area of exposure: 0.5 cm²
REMOVAL OF TEST SUBSTANCE
- Washing: the test item was washed from the epidermises with phosphate buffered saline.
- Time after start of exposure: 42 ± 1 min
- Post-treatment incubation period: 42 ± 1 h
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: cell viability (%)
- Value:
- 100
- Remarks on result:
- other:
- Remarks:
- Basis: other: mean value of negative controls (PBS). Time point: 42 min exposure, 42 h incubation. Reversibility: other: not applicable. (migrated information)
- Irritation / corrosion parameter:
- other: other: cell viability (%)
- Value:
- 114.8
- Remarks on result:
- other:
- Remarks:
- Basis: other: mean value of test item (pure). Time point: 42 min exposure, 42 h incubation. Reversibility: other: not applicable. (migrated information)
- Irritation / corrosion parameter:
- other: other: cell viability (%)
- Value:
- 2.9
- Remarks on result:
- other:
- Remarks:
- Basis: other: mean values of positve control (SDS, 5%). Time point: 42 min exposure, 42 h incubation. Reversibility: other: not applicable. (migrated information)
Any other information on results incl. tables
Table 1: MTT assay after 42 min exposure, 42 h incubation exposure
Negative control |
Positive control |
Test item |
Dead Ep. |
|||||||
Tissue sample |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
|
OD540 |
1.503 1.512 1.533 |
1.321 1.308 1.321 |
1.405 1.400 1.414 |
0.031 0.035 0.033 |
0.042 0.044 0.045 |
0.046 0.047 0.049 |
1.877 1.893 1.903 |
1.613 1.611 1.623 |
1.562 1.564 1.579 |
0.083 0.064 0.060 |
OD540(mean) |
1.516 |
1.317 |
1.406 |
0.033 |
0.044 |
0.047 |
1.891 |
1.616 |
1.568 |
0.069 |
OD540(mean values of replicates) |
1.413 |
0.041 |
1.692 |
0.069 |
||||||
Viability (%) |
100 |
2.9 |
119.7 |
4.9 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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