Registration Dossier
Registration Dossier
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EC number: 258-476-2 | CAS number: 53320-86-8
Endpoint summary
Administrative data
Description of key information
Test results for acute oral, dermal and inhalation toxicity are given below. At the concentrations used for these tests there were no fatalities in any of the tests and no abnormalities exhibited on necropsy. The actual values given in the test reports show that the values to be greater than the figures given here
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 200 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Exposure to large concentrations of this material in situations other than the manufacturing process is unlikely. It is generally included in formulations to control the viscosity of the end product and is normally only required at low concentrations (~ 1% or less). The most likely exposure in the work place is inhalation of dust during processing. This material has been manufactured and used commercially since the 1970’s. During more than thirty years of its manufacture and use in formulated products we are not aware of any issues relating to the health of operators who come into daily contact with this material. As a result of short-term testing, the material is not considered to be toxic by ingestion, inhalation or dermal contact, even at high dose levels. There were no effects at the maximum tested concentrations of 2000 mg/kg orally or dermally. A whole-body inhalation study performed at a loading of 200mg/l over 1 hour resulted in no adverse effects.
Comments from test results and observation may indicate
Eyes: Direct contact may cause mild irritation as with any particulate matter
Skin: No significant irritation or systemic effects from single short-term exposure
Inhalation: May irritate the respiratory passage very slightly, but no evidence of adverse effects following exposure to dust or to sprayed aqueous mixtures during use
Oral: No adverse effects.
Justification for classification or non-classification
Results of acute toxicity testing indicate no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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