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EC number: 258-476-2 | CAS number: 53320-86-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09-25 February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out in a GLP facility by trained personnel using recommended OECD test methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Silicic acid, lithium magnesium sodium salt
- EC Number:
- 258-476-2
- EC Name:
- Silicic acid, lithium magnesium sodium salt
- Cas Number:
- 53320-86-8
- Molecular formula:
- Na0.7[Li0.3Mg5.5Si8O20(OH)4]
- IUPAC Name:
- magnesium(2+) lithium(1+) sodium bis(oxosilanebis(olate))
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 2000mg/kg body weight dosed once only
- No. of animals per sex per dose:
- Five female rats in total
- Control animals:
- no
Results and discussion
- Preliminary study:
- One female rat was dosed with 10 ml/kg oral gavage with the 200mg/ml of the test material in arachis oil giving a total initial dose of 2000mg/kg body weight. No mortality was observed so a further 4 female rats were treated to the same dose.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Hunched posture on day of dosing in three rats. Nothing after that.
- Gross pathology:
- No abnormalities were noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information no deaths nor abnormalities Criteria used for interpretation of results: EU
- Conclusions:
- This test material showed no signs of being acutely toxic by oral exposure to rats
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