Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given. The omission of a 3rd animal does not affect the outcome of classification.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
2 animals only
Principles of method if other than guideline:
Only a rough summary is available, but the method of application seems to be similar to OECD TG 405.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) 2,2'-thiobisacetate
EC Number:
246-131-9
EC Name:
Bis(2-ethylhexyl) 2,2'-thiobisacetate
Cas Number:
24293-43-4
Molecular formula:
C20H38O4S
IUPAC Name:
2-ethylhexyl 2-({2-[(2-ethylhexyl)oxy]-2-oxoethyl}sulfanyl)acetate
Test material form:
solid - liquid: suspension
Details on test material:
- Name of test material (as cited in study report): Weichmacher VP KA 9073
- Analytical purity: not reported

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Not reported
- Housing: Individually

Test system

Vehicle:
not specified
Controls:
no
Amount / concentration applied:
500 mg/100µL/animal
Duration of treatment / exposure:
single dose
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
other: overall observation
Basis:
other: two animals
Time point:
other: 7 days
Score:
0
Reversibility:
other: not applicable

Any other information on results incl. tables

The test substance was reported to be not irritating to the rabbit eye under the conditions of this study.

However, there are major reporting deficits, the eye scoring system is unclear and only two animals were treated.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Based on the study results, no classification is required.
Executive summary:

In an eye irritation study summary, 0.1 mL containing 500 mg of the test substance was instilled into the conjunctival sac of two New Zealand White rabbits. No further details were given in the short report. The substance was reported to be not irritating to the eye.