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EC number: 482-070-6 | CAS number: 1001354-72-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Standard Guideline GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 482-070-6
- EC Name:
- -
- Cas Number:
- 1001354-72-8
- Molecular formula:
- C8-H19-N-O
- IUPAC Name:
- (3R,4R)-3-aminooctan-4-ol; (3R,4S)-3-aminooctan-4-ol; (3S,4R)-3-aminooctan-4-ol; (3S,4S)-3-aminooctan-4-ol
- Details on test material:
- Description: Sample is a white solid at room temperature, Clear colourless liquid at 37°C
Batch: CEC-200803388-4
Purity: 98.4% - Determined under GLP conditions by Impact Analytical, report number R09-0013
Test substance storage: In freezer (5 -15°C) in the dark under nitrogen
Stability under storage conditions: Stable
Expiry date: 03 September 2010
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Details on in vitro test system (if applicable):
- SKIN PREPARATION
- Source of skin: Biopredic International, Rennes, France
- Type of skin: human
- Thickness of skin (in mm): 420 to 500 micrometers
- Membrane integrity check:
Skin membranes were thawed, mounted in the diffusion cell and the skin integrity was tested by permeation of tritiated water. 200 pL saline containing tritiated water (3.7 kBq) was applied to the donor chamber of the flow-through cells. The receptor fluid consisted of saline and was collected every hour up to 3 hours after application. At the end of the experiment, the tritiated water remainina at the donor chamber was removed with a pipet and the skin was dried with two cotton swarbs (Etos BV, Beverwijk, The Netherlands). The receptor fluid samples were analyzed bv LSC. Only the results from the skin membranes with a Kp < 4.5 x 10 -3 cm/h are reported.
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- 0.5%
- Parameter:
- percentage
- Absorption:
- ca. 51.4 %
- Remarks on result:
- other: 24 hours
- Remarks:
- SD (+/-) 8.9
- Dose:
- 10%
- Parameter:
- percentage
- Absorption:
- ca. 20.6 %
- Remarks on result:
- other: 24 hours
- Remarks:
- SD (+/-) 10.3
Any other information on results incl. tables
The Skin integrity tests indicated that all skin samples were acceptable for the study.
In the main study, a lag time of 2- 4 hours was observed prior to radoilable being detected in the receptor fluid for th 0.5% test concentration. This lag phase was 3 hours for the 10% test concentration. The percentage of test material penetrating the skin (absorbed) was greater at the lower test concentration of 0.5%, with approxiately 50% of the applied dose being absorbed, compared to approximately 20% absorbed at the 10% test concentration. The actual values are givi the summary table below.
The Flux (amount of compound penetrating per cm2 per hour) was almost 10 times greater at 10% test concentration compared to the 0.5% concentration.
Dose |
Recovery data (%) +/- SD |
Lag time (h) |
Flux (mg/cm2/h) |
||
Absorbed |
Not-Absorbed |
Total recovery |
|||
0.5% |
51.4 +/- 8.9 |
47.0 +/-6.0 |
98.5 +/- 7.9 |
2-4 |
1.22 +/- 0.33 |
10% |
20.6 +/- 10.3 |
85.2 +/- 16.8 |
105.8 +/- 8.7 |
2 |
11.3 +/- 6.4 |
Applicant's summary and conclusion
- Conclusions:
- 3-amino-4-octanol is capable at penetrating the skin at concentrations of 0.5 and 10%, which are representative of the concentrations in metal working fluids.
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