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Diss Factsheets
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EC number: 200-064-1 | CAS number: 50-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vivo
Description of key information
Link to relevant study records
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- no guideline available
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- A micronucleus assay was done at the end of a 14-day subchronic toxicity study.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
- Species:
- rat
- Strain:
- Fischer 344
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- once a day
- Post exposure period:
- 24 hours
- No. of animals per sex per dose:
- 5 M and 5 F
- Tissues and cell types examined:
- Bone marrow cells
- Conclusions:
- Interpretation of results (migrated information): negative
In a 1'-day toxicological study in rats, ASA did not induced micronucleus up to 750 mg/kg/day. - Executive summary:
A study combined a 14 -day toxicological study in rats with final examination of micronuclei in bone marrow erythrocytes. The resulst were negative and in line with existing literature ( MacGegor, 1990).
Reference
No MPCE in males up to 750 mg/kg bw/d, slightly positive in females at 750 mg/kg bw/day, not considered positive due to a low MPCE in the corresponding control female, compared to the other groups tested, including controls of positive controls 6 -MP and cyclophosphamide.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Furthermore all the other in vitro studies were negative.
Justification for selection of genetic toxicity endpoint
Micronucleus study in vivo is the recommended one for C&L.
Justification for classification or non-classification
As in vitro and in vivo studies are concluded negative , ASA is not classified for genotoxicty.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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