Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 920-632-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP but other quality assurance
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- Metal release in human digestive system was estimated through in vitro bio-accessibility test in extraction solvent that resembles gastric fluid (using HCl 0.07N at pH 1.5) in accordance with the ASTM D 5517-07 standard. Metal released to the medium were determined after 1 hour of agitation at 171 rpm and another hour to allow the sample to settle at 37°C.
- GLP compliance:
- no
- Remarks:
- other quality assurance
Test material
- Reference substance name:
- Slag, nickel smelting
- IUPAC Name:
- Slag, nickel smelting
- Details on test material:
- The following sample was assesed:
Sample Code Sample size Description
4683 Less 500 μm C2 Nickel Slag, Granules
Sample collection made according to the C2-sampling protocol (see IUCLID section 1.4)
Constituent 1
Administration / exposure
- Vehicle:
- other: HCl 0.07N ,pH 1.5
- Duration and frequency of treatment / exposure:
- 1 hour agitation and 1 hour to allow the sample to settle
Results and discussion
Any other information on results incl. tables
Results provide a conservatove estimate of the bioaccesability of metals in nickel slag after ingestion.
Table 1.Bio-elution results of slag samples in gastric mimetic fluid. Test media was HCl 0.07N, pH 1.5 with 200 mg/L sample loading, an agitation rate of 171 rpm and 37°C. MDL= method detection limit (MDL) considering the dilution of the samples at 200 mg/L loading; BDL = Below detection limit (below MDL); Mean = Average concentration; SD = Standard deviation.
Sample |
Metal |
Bio-elution (200 mg/L), µg/L Mean CV, % |
MDL, µg/L |
4883 C2 Slag granules |
Cu |
7.8 10 |
0.8 |
Ni |
16.1 11 |
0.6 |
|
As |
BDL - |
2 |
|
Pb |
BDL - |
0.4 |
|
Zn |
BDL - |
10 |
|
Cd |
0.03 27 |
0.02 |
|
Mo |
BDL - |
3 |
|
Co |
16.36 15 |
0.01 |
Applicant's summary and conclusion
- Conclusions:
- The study can be used to estimate the amounts of metals in nickel slag that are readily available for absorbtion and support conclusions on hazard classification.
- Executive summary:
In-vitro bio-accessibility tests were performed in solvent that resembles gastric fluid ( using HCl at pH 1.5) according to ASTM D5517.07.
The fraction of metals that solubilize under these conditions can be considered as worst case determinant of bio-accessibility of metals contained in the slag. Results demonstrate reduced relative bio- accessibility of metals (Cu 0.04, Ni 0.05, Co 0.06).Dissolved concentrations of Pb and As were below detection limit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
