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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented study performed according to internationally accepted method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
Study was performed to evaluate the potential skin irritant effects of copper slag based on EU B4 method - Acute toxicity - Skin irritation. The tested substance was applied in a single dose on the skin of laboratory animals, using the untreated skin areas as control.
GLP compliance:
no
Remarks:
other quality assurance

Test material

Constituent 1
Reference substance name:
Slag, copper smelting
IUPAC Name:
Slag, copper smelting

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
Rabbit healthy adult male albino
The diet was standard for these animals. Animal house temperature was maintained at 20 + / - 2c, the relative humidity was between 30 -70% and photoperiod was 12/12 hours light / dark

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Controls:
yes, concurrent no treatment
Duration of treatment / exposure:
single dose
Observation period:
24, 48 and 72 hours
Number of animals:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Time point:
other: 72h
Score:
0
Irritation parameter:
edema score
Time point:
other: 72h
Score:
0
Irritant / corrosive response data:
No formation of erythema observed
No formation of edema observed

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
This is a good quality study. The sample is not skin irritant
Executive summary:

Study was performed to evaluate the potential skin irritant effects of copper slag based on EU B4 method - Acute toxicity - Skin irritation.

Based on the results, copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility of corrosion, defined as a strategic destruction of tissues throughout the skin thickness