Registration Dossier
Registration Dossier
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EC number: 212-201-2 | CAS number: 768-94-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 300 mg/L
- EC10 or NOEC for microorganisms:
- 32 mg/L
Additional information
Toxicity to microorganisms was evaluated in a GLP approach according to OECD guideline 209 using domestic non-adapted activated sludge as inoculum (BASF 2011). As test substance amantadine hydrochloride was used which is structurally similar to amantadine. After an incubation period of 180 minutes the EC10 was estimated to be 32 mg/L while the EC50 was measured to be 300 mg/L.
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