Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-study according to OECD/EU guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical monitoring:
yes

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
1.05 h-1
DT50:
0.66 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
0.38 h-1
DT50:
1.81 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
0.29 h-1
DT50:
2.38 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
30 °C
Hydrolysis rate constant:
0.04 h-1
DT50:
15.37 h
Type:
(pseudo-)first order (= half-life)

Applicant's summary and conclusion

Conclusions:
The substance is hydrolytically not stable.