Registration Dossier
Registration Dossier
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EC number: 266-104-5 | CAS number: 66069-34-9
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test material could be broken down into two parts clavulanic acid and Tertiary butylamine, therefore testing was conducted on each part of the test material at a pH of 4, 7 and 9.
At all three pH's tested the Tertiary butylamine was calculated to have a half life of > 1 year.
Key value for chemical safety assessment
Additional information
Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test material could be broken down into two parts clavulanic acid and Tertiary butylamine, therefore testing was conducted on each part of the test material at a PH of 4, 7 and 9. The results can be seen below:
Component |
pH |
Rate constant (hr-1) |
Estimated half-life at 25 °C |
Tertiary butylamine |
4 |
- |
>1 year |
7 |
- |
>1 year |
|
9 |
- |
>1 year |
|
Clavulanic acid |
4 |
2.91 x 10-2 |
23.9 hours |
7 |
1.19 x 10-2 |
58.4 hours |
|
9 |
3.09 x 10-2 |
22.4 hours |
At all three pH's tested the Tertiary butylamine was calculated to have a half life of > 1 year. The clavulanic acid part of the molecule had a half life of around 24 hours in acidic and slightly alkaline conditions, the halflife was a little longer in neutal conditions 58.4 hours.
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