Registration Dossier
Registration Dossier
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EC number: 610-954-5 | CAS number: 53075-09-5
Endpoint summary
Administrative data
Description of key information
LD50, rat, oral > 300 < 2000 mg/kg bw (BASF SE, 2008)
Key value for chemical safety assessment
Additional information
Oral:
In the key study, that was performed according to OECD guideline 423 in compliance with GLP, single doses of 2000 and 300 mg/kg body weight of the test material Adamantyltrimethylammoniumhydroxid 20% or test material preparations in doubly distilled water were given to three test groups of three fasted female animals each, (2000 mg/kg bw in 3 females, 300 mg/kg bw in 6 females) by gavage in a sequential manner (BASF SE, 2008). Under the conditions of this study the LD50 of Adamantyltrimethylammoniumhydroxid 20% after oral administration was found to be greater than 300 mg/kg and less than 2000 mg/kg body weight in rats.
Dermal:
There are no data available concerning acute dermal toxicity.
Inhalation:
There are no data available concerning acute inhalation toxicity.
Justification for classification or non-classification
EU classification according to Annex VI of Directive 67/548/EEC:
- Oral route: Xn, R22- Dermal route: no classification due to lacking data
- Inhalation route: no classification due to lacking data
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
- Oral route: Acute toxicity Cat. 4; H302
- Dermal route: no classification due to lacking data
- Inhalation route: no classification due to lacking data
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