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Description of key information

LD50, rat, oral > 300 < 2000 mg/kg bw (BASF SE, 2008)

Key value for chemical safety assessment

Additional information

Oral:

In the key study, that was performed according to OECD guideline 423 in compliance with GLP, single doses of 2000 and 300 mg/kg body weight of the test material Adamantyltrimethylammoniumhydroxid 20% or test material preparations in doubly distilled water were given to three test groups of three fasted female animals each, (2000 mg/kg bw in 3 females, 300 mg/kg bw in 6 females) by gavage in a sequential manner (BASF SE, 2008). Under the conditions of this study the LD50 of Adamantyltrimethylammoniumhydroxid 20% after oral administration was found to be greater than 300 mg/kg and less than 2000 mg/kg body weight in rats.

Dermal:

There are no data available concerning acute dermal toxicity.

Inhalation:

There are no data available concerning acute inhalation toxicity.

Justification for classification or non-classification

EU classification according to Annex VI of Directive 67/548/EEC:

- Oral route: Xn, R22

- Dermal route: no classification due to lacking data

- Inhalation route: no classification due to lacking data

GHS classification according to Annex I 1272/2008 CLP (EU GHS):

- Oral route: Acute toxicity Cat. 4; H302

- Dermal route: no classification due to lacking data

- Inhalation route: no classification due to lacking data

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