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EC number: 610-954-5 | CAS number: 53075-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
There are no data available concerning effects on fertility.
Effects on developmental toxicity
Description of key information
OECD 414, rat, oral (gavage): NOAEL maternal and developmental effects = 1000 mg/kg/d
Additional information
In the key study (BASF SE, 2010), that was performed according to OECD guideline 414 in compliance with GLP, Adamantyltrimethylammoniumhydroxide 20% was administered to pregnant Wistar rats daily by gavage from implantation to one day prior to the expected day of parturition (GD 6 - 19). Analyses confirmed the correctness of the prepared concentrations and the stability of the test substance.
There were no test substance-related effects on the dams concerning mortality, food consumption, body weight, body weight gain, gestational parameters, uterine and placental weights, as well as necropsy observations up to and including a dose of 1000 mg/kg bw/day. The high-dose (1000 mg/kg bw/d) caused transient (for a few minutes) salivation directly after treatment, which was likely to be induced by the bad taste of the test substance or by local irritation in the upper digestive tract of dams. It is not considered to be a sign of systemic toxicity. Salivation was not observed after treatment with lower doses.
Fetal examinations revealed no influence of the test compound on sex distribution of the fetuses and fetal body weights. Adamantyltrimethylammoniumhydroxide 20% shows no direct and specific effect on fetal morphological structures.
In conclusion, the no observed adverse effect level (NOAEL) of Adamantyltrimethylammoniumhydroxide 20% for maternal and prenatal developmental toxicity was determined to be 1000 mg/kg bw/day.
Justification for classification or non-classification
EU classification according to Annex VI of Directive 67/548/EEC:
- Effects on fertility: No classification due to lacking data - Developmental toxicity/teratogenicity: Conclusive, but not sufficient for classification
GHS classification according toAnnex I 1272/2008 CLP (EU GHS):
- Effects on fertility: No classification due to lacking data
- Developmental toxicity/teratogenicity: Conclusive, but not sufficient for classification
Additional information
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