Borate cobalt(2+) C3/C8/C10 carboxylates salts

Endpoint summary

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

Skin irritation

Reliable in vivo skin irritation studies described in Kukulinski (2011 & 2012) conducted on the three Borate Cobalt carboxylates (OECD 404 (modified), GLP compliant) are considered to be reliable without restrictions. As Cobalt(2+) Borate C3/C8/C10 carboxylates salts composition is a combination of the 3 cobalt borate carboxylates complexes tested for skin, conclusions of absence of irritation in the 3 compounds can thus be used to conclude in a similar way for the Cobalt(2+) Borate C3/C8/C10 carboxylates salts.

Eye irritation

Three reliable in vitro studies described by Heppenheimer conducted on the three Borate Cobalt carboxylates (OECD 437; GLP compliant) are considered to be reliable without restrictions. The threshold of the mean in vitro irritation score for corrosivity / severe irritancy is a score equal or higher than 55.1. All of the three eye irritation scores are clearly below this threshold.

Three reliable in vivo studies described by Sanders conducted on the three Borate Cobalt carboxylates (OECD 405; GLP compliant) are considered to be reliable without restrictions. The Cobalt borate 2-ethylhexanoate and Cobalt borate neodecanoate were determined to cause irritating effects on the eye whereas Cobalt borate propionate was determined to be severely irritating to the eye. As a worst case approach, Cobalt(2+) Borate C3/C8/C10 carboxylates salts can thus be considered as severely irritating to the eye.

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin irritation

References Kukulinski are the key studies for in vivo skin irritation and will be used for classification. The skin irritation was scored according to the Draize scale. The mean score (24, 48, 72h) for erythema and oedema was 0 for all animals. The studies were terminated after the 72 hour observation. According to regulation (EC) 1272/2008 and subsequent amendments the substance does not need to be classified as skin irritant.

Eye irritation

Cobalt borate 2-ethylhexanoate produced mild iridial inflammation, moderate conjunctival irritation and diffuse corneal opacity; the effects were fully reversible within 21 days. Cobalt borate neodecanoate produced conjunctival redness at the threshold of ≥ 2 as well as reversible effects within 14 days. The classification criteria according to regulation (EC) 1272/2008 as irritating to the eye are met (Category 2) for both substances.

Cobalt borate propionate showed severe irritating effects in cornea, iris and conjunctivae. The classification criteria according to regulation (EC) 1272/2008 as severe eye irritation are met., hence the substance will be classified as severe eye irritant (Category 1, R41).

Thus, as a worst case approach, the Salt reaction of borate, cobalt(2+) and C3/C8/C10 carboxylates will be classified as severe eye irritant (Category 1) according to regulation (EC) 1272/2008.