Registration Dossier
Registration Dossier
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EC number: 241-620-3 | CAS number: 17636-10-1
Endpoint summary
Administrative data
Description of key information
Additional information
Bioaccumulation: aquatic / sediment
No measured data regarding bioccumulation is available. However, the bioconcentration factor (BCF) of the test substance can be determined by the computer program BCFBAFWIN v3.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2011). Furthermore, the whole body primary biotransformation rate estimation for fish was calculated with the notation that the bio half-life normalized to 10 g fish at 15 °C. It is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper). Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was calculated. Using the Arnot-Gobas method, which is based on the mechanistic first principles, the BCF results in a value of 0.90 L/kg wet-wt. The whole body primary biotransformation rate estimate for fish gives a half-life of 0.004869 days, whereby the rate constant (kM) for 10 g fish is designed as 125/day. This is taken into account to predict the apparent metabolism half-life in fish for the substance. For the lower trophic level a BCF of 0.9410 L/kg wet-wt is calculated, whereas for the mid trophic level the BCF will result in 0.9323 L/kg wet-wt and the higher trophic level gives a value of 0.8937 L/kg wet-wt. The metal compounds (Na, K, Li) were removed for its calculation procedure. This procedure is regarded as a scientifically accepted calculation method and can be considered as reliable with restrictions. Furthermore, it can be used for the chemical safety assessment.
Bioaccumulation: terrestrial
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