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EC number: 241-620-3 | CAS number: 17636-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
1. Skin irritation (1987), GLP, OECD 404, rabbits, occlusive, 0.5 mL of undiluted test substance, not irritating
2. Eye irritation (1987), GLP, OECD 405, rabbits, 0.1 g of pure test substance, not irritating
3. Prediction using TOXTREE (v.2.5.0), Chemservice S.A., 2011
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
The skin irritation potential of the test substance was investigated in rabbits (Dickhaus and Heisler, 1987). 1-Propanesulfonic acid, 3-mercapto-, monosodium salt was applied to the shaved or shaved and abraded skin of rabbits (0.5 mL undiluted substance moistened with water (1:1)) for 24 hours under occlusive conditions. The study was performed according to the OECD Guideline 404 with no deviations and according to the good laboratory practice principles, it is considered to be of high quality (reliability Klimisch 2). The criteria of validity of the test system are fulfilled. After this period the skin was evaluated after 24, 48 and 72 hours and 7 days. After 24 -hours, or at any later time point no changes of the skin of any animal were observed. Because these observations occurred under the existing strict experimental conditions, the product can be regarded as not irritating to the skin. The contact of the product as a powder with the normal human skin can not be considered as dangerous. With an index of zero for primary irritation, the product 1-Propanesulfonic acid, 3-mercapto-, monosodium salt (MPS) is considered to be not irritating to the skin (ETAD SUBCOMMITTEE FOR TOXICOLOGY).
Eye irritation:
1-Propanesulfonic acid, 3-mercapto-, monosodium salt (MPS) was investigated for its potential to cause irritation in the rabbit eye according to OECD TG405 (Dickhaus and Heisler, 1987). The study was performed according to the OECD Guideline 405 without deviations and according to the good laboratory practice principles, it is considered to be of the highest quality (reliability Klimisch 1). The criteria of validity of the test system are fulfilled. 0.1 g of pure substance was instilled into the conjunctival sac, the untreated eye served as control. The reading of eye changes was performed after 1, 2, 4, 8, 24, 48, 72 and 96 hours and after 7 days. Only slight redness of the conjunctiva and slight chemosis occurred, which was all reversible within 4 hours. Therefore the test substance is considered to be not irritating to the eyes. According to classification criteria in EU Directive 67/548/EWG and EG Regulation 1272/2008 the test substance is not irritating to eyes and should be unclassified.
Prediction using Toxtree
For the estimation of eye irritation/corrosion potential of 1-Propanesulfonic acid, 3-mercapto-, monosodium salt was entered into the Toxtree modelling tool. 1-Propanesulfonic acid, 3-mercapto-, monosodium salt is assessed as not eye and skin corrosive.For eye irritation and corrosion “no skin corrosion R34 or R35” is predicted (taking into account the calculated melting point above 200°C). No skin corrosion or irritation potential is identified (taking into account the calculated melting point above 200°C).
Justification for classification or non-classification
Skin irritation:
According to the European regulation (EC) No. 1272/2008 the test material does not meet the criteria for classification and will not require labelling as irritating to the skin.
Eye irritation:
The mean grades of ocular reactions at 24, 48 and 72 h p.a. were lower than the value classified as irritating to the eyes by the European regulation (EC) No. 1272/2008, therefore the substance should not be classified.
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