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EC number: 241-620-3 | CAS number: 17636-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Urotoxicity of Oxazaphosphorine Cytostatics and its Prevention-III. Profile of Action of Sodium 2-mercaptoethane Sulfonate (Mesna)
- Author:
- Brock, N., Pohl, J., Stekar, J., Scheef, W.
- Year:
- 1 982
- Bibliographic source:
- Eur J. Cancer Clin Oncol., Vol. 18. No. 12, pp: 1377-1387, 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Repeated i.v. administartion with Mesna was carried out for six weeks on Sprague Dawley rats (10 per dose and sex) with three dose levels, including one toxic dose.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mesna
- EC Number:
- 243-285-9
- EC Name:
- Mesna
- Cas Number:
- 19767-45-4
- IUPAC Name:
- sodium 2-sulfanylethanesulfonate
- Test material form:
- other: solution
- Details on test material:
- - Name of test material (as cited in study report): MESNA (in the form of sodium salt)
- Molecular formula (if other than submission substance): C2H5NaO3S2
- Molecular weight (if other than submission substance): 164.18
- Smiles notation (if other than submission substance): C(S)CCS(=O)(=O)O{-}.[Na]{+}
- InChl (if other than submission substance): 1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig.1
- Substance type: organosulphur compound
- Physical state: pulver (Sigma Aldrich)
- Analytical purity: 98%
The test material was tested for identity and purity by the chemical laboratories of Asta-Werke under the guidance of Drs. Niemeyer, Scheffler and Weigert.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BD II and BD IX
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: the animals were obtained from breeding facilities of Degussa Pharma Group, Germany
- Housing: accordingly
- Diet (e.g. ad libitum): ad libitum (Altromin 1324 diet)
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Remarks:
- as a 40% solution
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- daily treatments
Doses / concentrations
- Remarks:
- Doses / Concentrations:
three dose levels including one non-toxic dose.
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- 1 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: The dose was tolerated without side effects.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a 6-week toxicity experiment Sprague Dawley rats tolerated daily intravenous doses of up to 1000 mg/kg bw .
- Executive summary:
Mesna is a pharmacologically unremarkable, physiologically largely inert and almost totally non-toxic thio compound (Brock et al., 1982). In the frame of studies on prevention of urotoxicity induced by oxazaphosphorine, toxicity potential of Mesna was studied in studies of different durations in rats and dogs. Repeated i.v. administartion with Mesna was carried out for six weeks on Sprague Dawley rats (10 per dose and sex) with three dose levels, including one toxic dose. Low toxicity of Mesna was confirmed in this experiment. The animals tolerated daily intravenous doses of up to 1000 mg/kg bw. The only sign of toxicity under the highest dosage was a retardation of the weights development.
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