Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The adsorption study was conducted to evaluated the adsorption of the test subsnatce according to OECD TG 121 with GLP. According to the guidelines, the determination of the Koc for test substances that are ionized for at least 10% within pH 5.5 to 7.5 should be performed with both the ionized and non-ionized form. Therefore, the pKa values of the test substance were calculated using the Perrin calculation method (pKalc 5.0, module in Pallas 3.0, CompuDrug International San Francisco, CA, USA). Based on the calculations, the HPLC analysis was performed at neutral pH. In a first test, solutions of references substances and the test substance were analysed but no peaks were observed in the chromatograms of E-200. In order to be sure that this was not due to the matrix of the test solution used in the first test (i.e. mobile phase), it was decided to perform an additional test using a test solution in tetrahydrofuran. The concentration of the test substance solution was 10.7 mg/l. And the concentration of the test substance solution was 103 mg/l.

Thus the Adsorption coefficient Koc of E-200 is >4.3 x 105 (log Koc >5.63) based the first and the additional test result.