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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to guidelines/standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
reporting details
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-nitrophenol
EC Number:
201-857-5
EC Name:
2-nitrophenol
Cas Number:
88-75-5
Molecular formula:
C6H5NO3
IUPAC Name:
2-nitrophenol
Details on test material:
- Name of test material (as cited in study report): o-Nitrophenol
- Physical state: solid
no further details provided

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: aqueous traganth suspension
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2% and 10% aqueous suspension with Traganth
Doses:
3200, 1600, 200 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily except weekends
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 3/10 animals died at the highest dose
Mortality:
At 3200 mg/kg bw 1/10 male and 2/10 female rat died after 24 hours.
Clinical signs:
other: At 3200 mg/kg bw: 90 min after application slight atony, abdominal position, stagger and tremor was seen. These symptoms were also seen on day 1 after treatment. At the following 2 days the surviving animals showed still slight atony. Thereafter the anima
Gross pathology:
Sacrificed animals showed no abnormalities. Dead animals showed stomacs filled with substance.

Applicant's summary and conclusion