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Registration Dossier
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EC number: 201-857-5 | CAS number: 88-75-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Manufacturer / producer data without proof (secondary source).
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Rhone-Poulnec Chimie Courbevoie Cedex
- Year:
- 1 976
- Bibliographic source:
- IUCLID Chemical Data Sheet, edited 2000-02-19
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of ortho-Nitrophenol
- Author:
- Randall DJ, Bannister RM
- Year:
- 1 976
- Bibliographic source:
- Acute Toxic Data, 1(1), 74 (1990)
Materials and methods
- Principles of method if other than guideline:
- The test material was tested for acute dermal toxicity and semiocclusively applied to rabbits for 24 hours.
- GLP compliance:
- not specified
- Test type:
- other:
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): ortho-Nitrophenol
- Analytical purity: 99.3 %
- Impurities: 0.3 % para-Nitrophenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST MATERIAL
- Concentration (if solution): 40 % in vehicle
TEST SITE
- Applied to intact, clipped skin - Duration of exposure:
- 24 hours
- Doses:
- 5010 mg/kg bw (1 rabbit), 7940 mg/kg bw (2 rabbits)
- No. of animals per sex per dose:
- 5010 mg/kg bw (1 rabbit), 7940 mg/kg bw (2 rabbits)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortalities occured.
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: Reduced appetite and activity was observed for 2-3 days.
- Gross pathology:
- Viscera of the animals apeared normal at sacrifice.
Applicant's summary and conclusion
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