Registration Dossier
Registration Dossier
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EC number: 201-857-5 | CAS number: 88-75-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Manufacturer / producer data without proof (secondary source).
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Rhone-Poulnec Chimie Courbevoie Cedex
- Year:
- 1 976
- Bibliographic source:
- IUCLID Chemical Data Sheet, edited 2000-02-19
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of ortho-Nitrophenol
- Author:
- Randall DJ, Bannister RM
- Year:
- 1 976
- Bibliographic source:
- Acute Toxic Data, 1(1), 74 (1990)
Materials and methods
- Principles of method if other than guideline:
- The test material was tested for acute dermal toxicity and semiocclusively applied to rabbits for 24 hours.
- GLP compliance:
- not specified
- Test type:
- other:
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): ortho-Nitrophenol
- Analytical purity: 99.3 %
- Impurities: 0.3 % para-Nitrophenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST MATERIAL
- Concentration (if solution): 40 % in vehicle
TEST SITE
- Applied to intact, clipped skin - Duration of exposure:
- 24 hours
- Doses:
- 5010 mg/kg bw (1 rabbit), 7940 mg/kg bw (2 rabbits)
- No. of animals per sex per dose:
- 5010 mg/kg bw (1 rabbit), 7940 mg/kg bw (2 rabbits)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortalities occured.
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: Reduced appetite and activity was observed for 2-3 days.
- Gross pathology:
- Viscera of the animals apeared normal at sacrifice.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
