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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity study with mice. Application: intraperitoneal; Observation: 14 days
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-nitrophenol
EC Number:
201-857-5
EC Name:
2-nitrophenol
Cas Number:
88-75-5
Molecular formula:
C6H5NO3
IUPAC Name:
2-nitrophenol
Details on test material:
- Name of test material (as cited in study report): o-Nitrophenol
- Physical state: solid
no further detail provided

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: traganth
Details on exposure:
concentration applied: 2%, 4%, and 16% (w/v)
Doses:
160, 200, 250, 400, 1600 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 200 mg/kg bw
Based on:
test mat.
95% CL:
162 - 256
Remarks on result:
other: mortality occured in all dose groups
Mortality:
1600 mg/kg: all animals died within 1 hour
400 mg/kg: all male animals died within 1 hour and 4/5 females died within one 1 hour
250 mg/kg: 2/5 males and 2/5 females died within one hour; day 7 after treatment 3/5 males and 4/5 females were dead
200 mg/kg: 1/5 males and 1/5 females died within one hour; one more male died after 48 hours and one more female died after 7 days and after 14 days.
160 mg/kg: 2/5 males died 7 days after treatment and 1/5 females died on day 7 after treatment
Clinical signs:
dyspnea, stagger, tremor, abdominal and lateral position, convulsions
Gross pathology:
intraabdominal adhesions

Applicant's summary and conclusion