Registration Dossier
Registration Dossier
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EC number: 201-857-5 | CAS number: 88-75-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute toxicity study with mice. Application: intraperitoneal; Observation: 14 days
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): o-Nitrophenol
- Physical state: solid
no further detail provided
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: traganth
- Details on exposure:
- concentration applied: 2%, 4%, and 16% (w/v)
- Doses:
- 160, 200, 250, 400, 1600 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 162 - 256
- Remarks on result:
- other: mortality occured in all dose groups
- Mortality:
- 1600 mg/kg: all animals died within 1 hour
400 mg/kg: all male animals died within 1 hour and 4/5 females died within one 1 hour
250 mg/kg: 2/5 males and 2/5 females died within one hour; day 7 after treatment 3/5 males and 4/5 females were dead
200 mg/kg: 1/5 males and 1/5 females died within one hour; one more male died after 48 hours and one more female died after 7 days and after 14 days.
160 mg/kg: 2/5 males died 7 days after treatment and 1/5 females died on day 7 after treatment - Clinical signs:
- dyspnea, stagger, tremor, abdominal and lateral position, convulsions
- Gross pathology:
- intraabdominal adhesions
Applicant's summary and conclusion
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