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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Classification and Labelling of Dangerous Substances. Recommended form to be used by the Working group on the Classification and Labelling of Dangerous Substances in order to update Annex I of Directive 67/548/EEC.
Author:
Anonymous
Year:
1993
Bibliographic source:
Commission of the European Communities DG XI
Report date:
1993
Reference Type:
secondary source
Title:
Mononitrophenols
Author:
International Programme on Chemical Safety (IPCS)
Year:
2011
Bibliographic source:
http://www.inchem.org/documents/cicads/cicads/cicad_20.htm (query result from 2011-10-14)
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
not specified
Principles of method if other than guideline:
The test substance was tested for its sensitising potential in the Buehler Test with guinea pigs.
GLP compliance:
not specified
Type of study:
Buehler test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-nitrophenol
EC Number:
201-857-5
EC Name:
2-nitrophenol
Cas Number:
88-75-5
Molecular formula:
C6H5NO3
IUPAC Name:
2-nitrophenol
Details on test material:
- Name of test material (as cited in study report): o-Nitrophenol, 2-Nitrophenol
- Physical state: Solid
- Analytical purity: 99.6 %
- Impurities (identity and concentrations): ~ 0.3 % p-Nitrophenol

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
no data
Challengeopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
no data
Details on study design:
no data
Challenge controls:
no data
Positive control substance(s):
not specified

Results and discussion

Any other information on results incl. tables

The test substance was found to be not sensitising in the Buehler Test.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information