Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 210-848-5 | CAS number: 624-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption, distribution: Systemic effects indicated an absorption of the test substance in the gastrointestinal tract. The dermal absorption is estimated to be low. Absorption after inhalation was observed.
The water solubility is rather high (78 g/L), the n-octanol/water partition coefficient is low (logPow = 0.52), the molecular mass is low (144), therefore it is anticipated also from the physico-chemical parameters that the substance is able to penetrate biological membranes to some extent.
Metabolism: No indication of the importance of the metabolism was obtained.
Excretion: No relevant data are available.
Bioaccumulation: From the low logPow no relevant bioaccumulation potential is anticipated.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The toxicokinetic behaviour of dimethyl maleate was estimated from available data for the purpose of registration of the substance.
Absorption, distribution: Systemic effects were detected in the acute and subacute oral toxicity study at high doses, indicating an absorption of the test substance in the gastrointestinal tract.
No indication for a dermal absorption was obtained from the acute dermal toxicity study. The difference between oral and dermal acute toxicity indicate a low or a slow dermal absorption. Systemic effects were observed in a subacute dermal toxicity study with rats at high doses, indicating a dermal absorption to some degree. A slight dermal absorption is also derived from the positive skin sensitisation study (GPMT). The rather high water solubility and the low n-octanol/water partition coefficient would impede a dermal absorption, whereas the low molecular mass would favour it.
The vapour pressure is medium, the saturation concentration only produced death in rats after ca. 8 h exposure.
The water solubility is rather high (78 g/L), the n-octanol/water partition coefficient is low (logPow = 0.52), the molecular mass is low (144), therefore it is anticipated also from the physico-chemical parameters that the notified substance is able to penetrate biological membranes to some extent.
Metabolism: No genotoxicity was detected in the bacterial reverse mutation assay with and without metabolizing enzymes and no indication of the importance of the metabolism of the notified substance was obtained from this study.
Excretion: No relevant data are available, which could provide evidence on the route and extent of excretion.
Bioaccumulation: No statement on the bioaccumulation can be derived from the comparison of the effective doses in the acute and the repeated dose dermal toxicity study, when also considering the different extent of the investigations in both studies. From the low logPow no relevant bioaccumulation potential is anticipated.
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