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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
secondary source
Title:
Unnamed
Year:
2000

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl maleate
EC Number:
210-848-5
EC Name:
Dimethyl maleate
Cas Number:
624-48-6
Molecular formula:
C6H8O4
IUPAC Name:
dimethyl (Z)-but-2-enedioate
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Amount / concentration applied:
100 µL
Observation period (in vivo):
7 days p.a.
Number of animals or in vitro replicates:
2
Details on study design:
Instillation into the conjunctival sac of the eyes.

Results and discussion

In vivo

Irritant / corrosive response data:
highly irritating

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The test item was highly irritating to the eyes of rabbits.
Executive summary:

0.1 mL substance was instilled into the conjunctival sac of rabbits, which were observed for 7 days.

The test item was highly irritating.

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