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EC number: 210-848-5 | CAS number: 624-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, publication/study report which meets basic scientific principles, but details missing
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 276-328 g - Route:
- intradermal and epicutaneous
- Vehicle:
- other: ethanol
- Concentration / amount:
- 1 % test substance in ethanol for all administrations
- Route:
- other: epicutaneous, no more data
- Vehicle:
- other: ethanol
- Concentration / amount:
- 1 % test substance in ethanol for all administrations
- No. of animals per dose:
- 10 test substance group animals, 5 control animals
- Details on study design:
- applied volumes: 0.1 mL (intradermal), 0.5 mL (dermal)
- Positive control substance(s):
- not specified
- Reading:
- other: first and second readings
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.005 mL test substance
- No. with + reactions:
- 10
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: first and second readings. . Hours after challenge: 48.0. Group: test group. Dose level: 0.005 mL test substance. No with. + reactions: 10.0. Total no. in groups: 10.0.
- Reading:
- other: first and second readings
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.005 mL test substance
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: other: first and second readings. . Hours after challenge: 48.0. Group: negative control. Dose level: 0.005 mL test substance. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DMM has a strong skin sensitising potential according to the GPMT (1%, all animals positive response).
- Executive summary:
The test substance was administered to a group of 10 female guinea pigs intradermally and epicutaneously, according to the scheme given in OECD 406 and the protocol of Magnusson and Kligman. A group of 5 guinea pigs served as negative controls.
48 and 72 hours after the start of the challenge exposure all animals of the test substance group showed very slight to severe erythema including slight eschar formation and very slight to severe edema. No adverse skin reactions were noted in the negative control group.
The results demonstrated that the test substance has a skin-sensitising potential.
Reference
See Attachment for results.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Justification for selection of skin sensitisation endpoint:
The only available study, a key study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
A clear sensitizing effect was observed when dimethyl maleate was applied repeatedly to skin.
The substance is a strong sensitizer according to CLP and the Guidance on Application of the the CLP-Criteria, section 3.4.2.3.4.3.
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