Registration Dossier
Registration Dossier
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EC number: 216-074-4 | CAS number: 1490-04-6
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special study
Data source
Reference
- Reference Type:
- publication
- Title:
- Glucuronidation of 7-hydroxy-4-methyl-coumarin by liver microsomes. Inhibition by certain drugs
- Author:
- Irshaid YM, Gharaybeh KI, Ammari FF, Rawshdeh NM
- Year:
- 1 990
- Bibliographic source:
- Eur J Drug Metabolism and Pharmacokinetics 15, 295-301
Materials and methods
- Principles of method if other than guideline:
- In an in vitro study with human liver samples the glucuronidation of 7-hydroxy-4-methylcoumarin (7-0H-4-MC) in the presence of menthol (isomer unspec.) was measured
- GLP compliance:
- not specified
- Type of method:
- in vitro
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- DL-menthol
- EC Number:
- 216-074-4
- EC Name:
- DL-menthol
- Cas Number:
- 1490-04-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Details on test material:
- Menthol was purchased from Sigma Chmical Co. (no data on purity)
Constituent 1
Constituent 2
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: in-vitro experiment
- Vehicle:
- other: in-vitro experiment
- Duration of treatment / exposure:
- not applicable (in-vitro experiment)
- Frequency of treatment:
- not applicable (in-vitro experiment)
- Post exposure period:
- not applicable (in-vitro experiment)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not applicable (in-vitro experiment)
Basis:
- No. of animals per sex per dose:
- not applicable (in-vitro experiment)
Results and discussion
- Details on results:
- In an in vitro study with human liver samples menthol (isomer unspec.) inhibited the glucuronidation of 7-hydroxy-4-methylcoumarin (45 % inhibition).
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
In an in vitro study with human liver samples menthol (isomer unspec.) inhibited the glucuronidation of 7 -hydroxy-4 -methylcoumarin ( 45% inhibition).
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