Registration Dossier
Registration Dossier
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EC number: 216-074-4 | CAS number: 1490-04-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Menthol glycuronic acid appeared in the urine of rabbits in less than an hour after gavage dosing menthol, and 90 per cent of the conjugated acid was found to be excreted in 6 hours when 2 g of menthol were feed. Even when larger doses were given over 90 per cent of the total amount excreted appeared in the urine during the first 24 hours.
In another study after a single oral administration of 1 g/kg bw of menthol racemic to rabbits, 59 % of the applied test substance was excreted as glucuronide with the urine within 2 d.
Consequently, high bioavailability is documented after oral application
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