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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997/07/17 - 1997/07/31
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dioctadecyl ether
EC Number:
228-567-1
EC Name:
Dioctadecyl ether
Cas Number:
6297-03-6
Molecular formula:
C36H74O
IUPAC Name:
1-(octadecyloxy)octadecane

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: IFFA-CREDO, 69210 -L'ARBRESLE, FRANCE
- Age at study initiation: about 6 weeks
- Weight at study initiation: 150g-157g (males), 137g-147g (females)
- Fasting period before study: fastening overnight
- Housing: 5 animals by sex in polypropylene cages
- diet: Complete pelleted rat maintenance diet UAR A04-10 (91360 - EPINAY SUR ORGE, FRANCE)
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
in accordance with the requirements of the 86/609/EEC guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: mineral oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 5000 mg/15mL
- Amount of vehicle (if gavage): 15 mL/kg bw
- Lot/batch no. (if required): 85H110

MAXIMUM DOSE VOLUME APPLIED: 15 mL/kg bw
Doses:
single dose of 5000 mg/kg under a constant volume of 15 mL/kg bw
No. of animals per sex per dose:
5 animals per dose and sex
Control animals:
no
Details on study design:
- Reason for route of administration: Oral gavage is the route of choice for estimating potential adverse effects resulting from accidental oral ingestion.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:observed daily and weighted on day 1, 4, 8, 15
- Necropsy of survivors performed: yes
- clinical examinations: at least once a day to evaluate the genaral appearance, the behavior and vegetative functions
- macroscopic examinations: rats are sacrificed after 14 observation days and then autopsied
Statistics:
no statistics

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occured.
Clinical signs:
other: No significant toxic effects on the animals behavior or vegetative functions occured.
Gross pathology:
Test substance does not cause any gross lesions visible at autopsy.

Applicant's summary and conclusion