Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2007-2008
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 B (Bioaccumulation: Semi-static Fish Test)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: colourless liquid
Details on test material:
GR-86-3794 (synonymous with CASSYRANE)
Lot No. LDP0700006
Purity: 97.8%
Date of Expiry : 29 July 2009
Radiolabelling:
no

Test organisms

Test organisms (species):
Carassius auratus

Study design

Route of exposure:
aqueous
Test type:
semi-static
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
30 d

Test conditions

Hardness:
Approx. 100 mg CaCO3/L
pH:
pH 6.4 to 6.7

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
>= 34.3 - <= 63.1 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Conc.in environment / dose:1 mg/L
Type:
BCF
Value:
>= 31.8 - <= 48.1 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Conc.in environment / dose:10 mg/L

Applicant's summary and conclusion

Conclusions:
The bioconcentration of CASSYRANE in Carassius auratus exposed over a period of 30 days in an OECD 305B test set-up under 48-hour semi-static renewal conditions was determined to be on average 39 L/kg wet wt. at the 10 mg/L exposure level and 52 L/kg wet wt at the 1 mg/L exposure level.