Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes (incl. QA statement)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Batch No. LQC0701302
Purity 98.1%

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Details on test solutions:
The carrier is DMF (Dimethylformamide) 0.93, 1.88, 3.75, 7.5, 15 mg test item/L. Additionnaly, a solvent control (100 mg DMF/L) and a control (test water without addition of the test item ) were tested on parallel.
All analytically determined test concentrations remained within 80 - 120% of nominal values. Results are presented based on nominal test concentrations.

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
7.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks on result:
other: 95% CI : 5.81 - 9.80

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Based on the test results the 96-hour LC50 og GR-86-3794 for ZebraFish (Danio rerio) was determined to be 7.5 mg test item/L absed on nominal concentrations.