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EC number: 701-497-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-11-02 to 1994-1-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified reliable without restriction. The study was conducted according to OECD 402 Guidelines and followed GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-dodecene dimer, hydrogenated
- IUPAC Name:
- 1-dodecene dimer, hydrogenated
- Details on test material:
- - Substance type: 1-dodecene dimer, hydrogenated
- Physical state: clear colourless liquid
- Lot/batch No.: C1527-04-2
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd., Kent, U.K.
- Age at study initiation: 10-14 weeks
- Weight at study initiation: Male: 212-244 grams; Female: 213-227 grams
- Fasting period before study: No
- Housing: Individually during exposure and groups of 5 by sex in polypropylene cages
- Diet (e.g. ad libitum): Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, Essex, U.K. ad libitum
- Water (e.g. ad libitum): Mains drinking water ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-24˚C
- Humidity (%): 50% - 69%
- Air changes (per hr): 15 per hour
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: 1994-11-02 To: 1994-1-16
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: 37 square centimeters
- Type of wrap if used: piece of surgical gauze measuring 10 cm x 5 cm was placed over the treatment area and secured with surgical tape (MICROPORE) wrapped around each end. The gauze was overarapped with cling film and elastic adhesive bandage (ELASTOPLAST).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, wiped with cotton wool moistened with distilled water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.51 mL/kg
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- Single application of 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for deaths or overt signs of toxicity 1, 2.5, and 4 hours after dosing and subsequently once daily for 14 days. The test sites were examined for evidence of dermal irritation approximately 30 minutes after bandage removal and on Days 3, 7, 10 and 14. Individual bodyweights were recorded prior to application of the test material on Day 0 and on Days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Based on the absence of mortality and lack of adverse treatment-related clinical toxicity in male and female rats
- Mortality:
- No mortality was observed in either male or female rats throughtout the study period.
- Clinical signs:
- other: There were no adverse treament-related signs of clinical toxicity observed in the study. No signs of skin irritation were noted during the study.
- Gross pathology:
- Gross necroscopy at termination did not reveal any remarkable findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the lack of test material related clinical toxicity and mortality, the acute dermal LD50 for 1 -dodecene dimer, hydrogenated is determined to be >2000 mg/kg body weight.
- Executive summary:
In an acute dermal toxicity study (Driscoll, R., 1995; Klimisch score = 1), 2000 mg/kg bw of 1 -dodecene dimer, hydrogenated were applied to the intact skin of Sprague-Dawley rats (5/sex). The test material was applied intact under semi-occlusive wrap for a period of 24 hours and animals observed over a 14 day period for signs of irritation and clinical toxicity.
No mortality was observed in either male or female animals through the study period. There were no adverse treament-related signs of clinical toxicity observed and no signs of skin irritation were noted during the study. Body weights of male and female rats remained unaffected through the study period. Gross necroscopy at termination did not reveal any remarkable findings.
Based on the lack of test material related clinical toxicity and mortality, the acute dermal LD50 for 1 -dodecene dimer, hydrogenated is determined to be >2000 mg/kg body weight.
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