Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Endpoint summary
Administrative data
Description of key information
Guideline, GLP skin and eye irritation studies are available for cloquintocet-mexyl technical (purity 91.6%). There was evidence of mild skin irritation which had fully reversed after 48 hours. There was some evidence of eye irritation which had fully reversed after 72 hours. The irritation seen was not of sufficient severity to warrant classification as a skin or eye irritant.
There is no data on respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
Cloquintocet-mexyl has been tested in rabbits (Schoch M, 1987). There was evidence of slight erythema after 1 and 24 hours which had fully reversed after 48 hours. There was no evidence of corrosion.
Eye irritation
Data on cloquintocet-mexyl indicate that instillation of liquid test substance into the conjunctival sac of the rabbit eye induced some irritation at 24 and 48 hours which had fully reversed after 72 hours. None of the eye findings were of a severity that warrants classification (Schoch M, 1987).
Respiratory irritation
There are no data.
Human information
There is no human information concerning skin or eye irritation.
Justification for classification or non-classification
Although there is some evidence of skin and eye irritation in response to administration of cloquintocet-mexyl, this is fully reversible and is not of sufficient severity to warrant classification:
- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.5 and 3.2.6.
- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.2.
- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.3.
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