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EC number: 260-375-3 | CAS number: 56773-42-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to aquatic invertebrates was determined with the read-across substance according to OECD 202 method and the test species Daphnia magna and is given to be EC50 = 61 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 61 mg/L
Additional information
Short-term toxicity to aquatic invertebrates was determined with the read-across substance according to OECD 202 method and the test species Daphnia magna and is given to be EC50 = 61 mg/L.
Read-across justification
Group: Tetraethylammonium heptadecafluorooctanesulphonate (56773-42-3) and Potassium perfluorooctanesulfonate (CAS no. 2795-39-3)
Justification: REACH regulation EC 1907/2006 and ECHA guidance document R.6 give that substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar, or follow a regular pattern as a result of structural similarity, may be considered as a group / category of substances.
- Chemical similarity: According to OECD, 2002, (ENV/JM/RD(2002)17/FINAL) “perfluorinated compounds represent a very unique chemistry”, at least substances with equal numbers of perfluorinated carbon atoms and functional groups. The 'Environmeltal Risk Evaluation Report' of Brooke et al., 2004, (Environment Agency, GB) differentiated perfluorinated substances in groups with PFOS itself being a group, consisting of salts with e.g. potassium and ammonium (including quartenary ammonium) as counter ion. Thus, in accordance with OECD, 2002, grouping and read-across based on the length of the perfluorinated C8 structure with a sulfonate moiety is very well justified. Furthermore, Brooke et al. gave that the C8 structure with sulfonate ending is positevely charged being opposed by a positively charged counter ion that might be potassium or tetraethylammonium.
The substance which is used for read-across is potassium perfluorooctanesulfonate which consists of a C8 structure, a sulfonate moiety and the counter ion potassium. Thus, the criterion of structural similarity is fulfilled.
- Physical behaviour: Both substances are organic salts which show surface activity and ionic properties which makes it impossible to determine partition coefficient (QSAR estimations are possible). The melting and boiling point of both substances are high and both are readily dissolvable in water. Thus, physicochemical porperties are also similar.
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